EBNA1 and Epstein-Barr Virus Associated Tumours (SpringerBriefs in Cancer Research)

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Epstein-barr virus-associated malignancies: epidemiologic patterns and etiologic implications.

She specializes in researching mechanisms by which viruses persist and induce cancer in human cells. According to Scopus, Dr. Frappier has an H-index of 25; she has published over 80 papers and has been cited over times. Please see attached short CV for additional details. JavaScript is currently disabled, this site works much better if you enable JavaScript in your browser. Biomedical Sciences Cancer Research. Buy eBook. Buy Softcover. FAQ Policy. Show all.

Conclusion Pages Frappier, Lori. Lawrence S. Charles Rabkin Prof. Download All Papers. Order results.

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Content type Publication Date. Normal Extended Compact. Select all. Error Ops Research Jump to: Review , Other. Open Access Feature Paper Communication. Gulley , G. Abstract Epstein-Barr virus EBV -positive gastric adenocarcinoma exhibits locally intense inflammation but systemic manifestations are uncertain. Our study examined whether circulating mediators of inflammation and immune response differ by tumor EBV status. From a Latvian series of gastric cancer cases, we measured plasma levels [ Epstein-Barr virus EBV -positive gastric adenocarcinoma exhibits locally intense inflammation but systemic manifestations are uncertain.

From a Latvian series of gastric cancer cases, we measured plasma levels of 92 immune-related proteins in the 28 patients with EBV-positive tumors and 34 patients with EBV-negative tumors. Profiling of these molecules may enable non-invasive diagnosis of EBV status when tumor tissue is unavailable. Our findings provide theoretical justification for clinical evaluations of immune checkpoint therapy for EBV-positive gastric cancer. Full article. Open Access Article. Abstract Infection of Epstein—Barr virus EBV , a ubiquitous human gamma herpesvirus, is associated with various malignancies in B lymphocytes and epithelial cells.

Although accumulating evidence demonstrates that EBV infection regulates [ Infection of Epstein—Barr virus EBV , a ubiquitous human gamma herpesvirus, is associated with various malignancies in B lymphocytes and epithelial cells. Although accumulating evidence demonstrates that EBV infection regulates the profile of microRNAs in the cells, little is known about the microRNAs in exosomes released from infected cells. We found that the biogenesis of exosomes is upregulated in type III latently infected cells compared with EBV-negative and type I latently infected cells.

We also observed that viral and several specific host microRNAs were predominantly incorporated in the exosomes released from the cells in type III latency. Our findings indicate that EBV infection, in particular in type III latency, modulates the biogenesis of exosomes and the profile of exosomal microRNAs, potentially contributing to phenotypic changes in cells receiving these exosomes. The experiment was performed three times independently and the average and its SD are shown in each condition. Isolated exosomes were subjected to a Bradford protein assay.

Relative amounts of protein are shown. The nuclei blue were counterstained with Hoechst Expression of CD63 or Alix in Mutu cells was measured by flowcytometry. Individual EBV genomes are shown in green. Four fields containing 10—20 nuclei were selected randomly and numbers of EBV genomes per cell were analyzed. Average and its SD are shown in each condition.

As an internal control, the human rhodopsin gene was used.


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Analysis was duplicated and average and its SD are shown. The average copy number of miRNA is shown.


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Ogwang , Steven J. Alignments of the [ Pattern A was found in Further research is needed to replicate and elucidate our findings.

Epstein-Barr Virus Sustains its Associated Cancers

Color shadows highlight the investigated regions or positions of each publication. Different color shades are used when the specific variations identified in the studied regions are different. Use of the same color shade at the same region, e. The relative positions of the variations correspond to the illustration of the LMP-1 gene on the top. The results are based on tests conducted in peripheral blood of children with BL and BL-free children recruited from the same geographical area as the cases. Dawson and Lawrence S. Abstract The Epstein—Barr virus EBV -encoded latent membrane protein 1 LMP1 oncogene can induce profound effects on epithelial growth and differentiation including many of the features of the epithelial-to-mesenchymal transition EMT.

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The Epstein—Barr virus EBV -encoded latent membrane protein 1 LMP1 oncogene can induce profound effects on epithelial growth and differentiation including many of the features of the epithelial-to-mesenchymal transition EMT. To better characterise these effects, we used the well-defined Madin Darby Canine Kidney MDCK epithelial cell model and found that LMP1 expression in these cells induces EMT as defined by characteristic morphological changes accompanied by loss of E-cadherin, desmosomal cadherin and tight junction protein expression.

These findings support an important role for LMP1 in disease pathogenesis through transcriptional reprogramming that enhances tumour cell survival and leads to a more invasive, metastatic phenotype. The heatmap highlights differences in the induction of various genes, which is noted by the difference in the intensity of the bars: blue low or red high. All samples were collected as part of the same biological triplicate and therefore the same loading control and LMP1 expression control are used throughout.

The histogram displays the average of technical triplicates for each sample, and is a representative of biological triplicate experiments. EBV-associated malignancies have increased by We have previously demonstrated that the EBV-deoxyuridine triphosphate nucleotidohydrolase dUTPase modulates innate and adaptive immune responses by engaging the Toll-Like Receptor 2 TLR2 , which leads to the modulation of downstream genes involved in oncogenesis, chronic inflammation, and in effector T-cell function.

Furthermore, examination of serum samples from diffuse large B-cell lymphoma DLBCL and chronic lymphocytic leukemia patients revealed the presence of increased levels of anti-dUTPase antibodies in both cohorts compared to controls with the highest levels 3. Using computer-generated algorithms, dUTPase amino acid sequence alignments, and functional studies of BLLF3 mutants, we identified a putative amino acid motif involved with TLR2 interaction. Binding of p65 to Qp was shown by chromatin immunoprecipitation ChIP analysis, while electrophoretic mobility shift assays EMSAs demonstrated that p50 can also bind to Qp.

The averages and standard errors of the mean SEM from three independent experiments are shown.

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The results are expressed as fold enrichment, where the rabbit control IgG was set to 1. The means and SEM from three independent experiments are shown, and all samples were analyzed in triplicate. Lane 2 shows the binding pattern of the nuclear extract from untransfected cells, while lane 3 shows the binding band associated with transfected cells, indicated by an arrow.

Lanes 4 and 5 show the binding of the probe when an excess of a competitor oligonucleotide was added to the binding reaction. Super-shift experiments with antibodies were performed as indicated above the gel; the super-shifted complex is indicated by an arrowhead.

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Nucleotide sequences of the double-stranded probes and oligonucleotides used in the competition experiments are shown below the gel image. The gel displayed is representative of results obtained in two independent experiments. The averages and SEM from at least two independent experiments are shown. The averages and SEM from three independent experiments are shown.